Blood Level Curves For Im And Sustained Release Dosage Form
The method is based on assumption that two dosage forms that exhibit superimposable plasma level-time profile in a group of subjects should result in identical therapeutic activity.
Blood level curves for im and sustained release dosage form. Sustained release constitutes any dosage form that. In controlled release dosage form the blood level is evenly maintained. Calculation of amount of drug required for designing a sustained release dosage form.
Blood levels from a sustained-release dosage form. Duration of action can be prolonged from 24hours to 12 months. Intramuscular / Subcutaneous route:.
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release ER, XR, XL dosage) or to a specific target in the body (targeted-release dosage). To be a good candidate for sustained release dosage form. Most of sustained release dosage form follows the mechanism of diffusion, dissolution or combination of both, to produce slow release of drug at predetermined rate.
Journal of Pharmaceutical Sciences, 01 Oct 1975, 64(10):. Find the latest articles and preprints. SUSTAINED RELEASE DOSAGE FORM • Sustained drug delivery may provide an immediate dose required for the normal therapeutic response, followed by the gradual release of drug in amounts sufficient to maintain the therapeutic response for a specific extended period of time usually 8-12 hours.
Dobrinska MR, Welling PG. Maximum 2ml or 2 gm can be administered through this route. Wetting time, in vitro disintegration thinks about, Curve fitting examination.
Blood levels from a sustained-release dosage form. Hypothetically, a sustained release dosage form should release the drug by a zero-order mechanism which maintains drug plasma level time similar to intravenous infusion. The areas under the curves of the plasmalevel vs time forthe threedosage forms were with· in 9 percent of each other.
Dose of the drug should not be too large, as a larger dose is to be incorporated into sustained release dosage form. The plasma concentration-time curve (blood level curve) is the focal point of. Riods of sub-therapeutic drug blood levels or those.
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